Rhodium catalysts derived from a fluorinated phanephos ligand are highly active catalysts for direct asymmetric reductive amination of secondary amines

Highly active catalysts of bisphosphine oxides for asymmetric Heck reaction.

Bisphosphine oxides formed highly active asymmetric Heck catalysts, which were applied in asymmetric synthesis of pharmacologically active azacycles. Olefin insertion proceeded via cis pathways, different from P,N-ligands.

Highly enantioselective hydrogen-transfer reductive amination: catalytic asymmetric synthesis of primary amines.

Optically active amines are attracting increasing interest in the food, agrochemical, and pharmaceutical industries as building blocks for novel compounds and as templates for asymmetric synthesis. One of the most common methods for preparing amines is the reductive amination of carbonyl compounds. We have successfully explored the rhodiumcatalyzed asymmetric reductive amination with hydrogen a...

Microwave synthesis of classically immiscible rhodium-silver and rhodium-gold alloy nanoparticles: highly active hydrogenation catalysts.

Noble metal alloys are important in large-scale catalytic processes. Alloying facilitates fine-tuning of catalytic properties via synergistic interactions between metals. It also allows for dilution of scarce and expensive metals using comparatively earth-abundant metals. RhAg and RhAu are classically considered to be immiscible metals. We show here that stable RhM (M = Ag, Au) nanoparticles wi...

Ligand-promoted ortho-C-H amination with Pd catalysts.

2,4,6-Trimethoxypyridine is identified as an efficient ligand for promoting a Pd-catalyzed ortho-C-H amination of both benzamides and triflyl-protected benzylamines. This finding provides guidance for the development of ligands that can improve or enable Pd(II)-catalyzed Csp2-H activation reactions directed by weakly coordinating functional groups.

Formal asymmetric biocatalytic reductive amination.